Anti-CADM1 Polyclonal Antibody,BR

英文名称： Anti-CADM1 Polyclonal Antibody
中文名称： 细胞粘附分子1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： WB
稀释比例： WB 1:500-1000.

靶标： CADM1
别名： BL2;IGSF4;IGSF4A;NECL2;Necl-2;RA175;ST17;SYNCAM;TSLC1;sTSLC-1;sgIGSF;synCAM1
背景说明： Homologous to the poliovirus receptor (PVR/CD155), the Nectin immunoglobulin superfamily comprises four known isoforms, Nectin 1, 2, 3 and 4 (also designated TSLC1). TSLC1 is encoded by a tumor-suppressor gene in human non-small-cell lung cancer mapping to chromosome 11q23.2. The TSLC1 protein is an N-linked membrane glycoprotein that co-localizes with the Actin filament-binding protein, afadin, at cadherin-based adherens junctions in MDCKII epithelial cells. TSLC1 also interacts with the tumor-suppressor gene product DAL-1 (for differentially expressed in adenocarcinoma of the lung protein 1) to target Actin rearragement and cellular motility. TSLC1 may also form homodimers that function in homophilic, intracellular adhesion. TSLC1 expression is reduced or absent in a number of characterized cancer cell lines including A549. In prostate and breast cancer, as well as in pancreatic ductal adenocarcinoma, the TSLC1 promoter is commonly silenced by hypermethylation. Unlike other Nectins, which are more widely expressed, TSLC1 is mainly expressed in the placenta.
Swiss Prot： Q9BY67
Gene ID： 23705
亚细胞定位： Cell junction Cell membrane Single-pass type I membrane protein synapse
免疫原： Recombinant protein of human CADM1
Public Immunogen Range： 45-344aa
理论分子量： 49kDa

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。