盐酸拓扑替康,98%
Topotecan hydrochloride
(订货以英文名为准)中文名称:
盐酸拓扑替康
英文名称:
Topotecan hydrochloride
CAS No.:
119413-54-6
分子式:
C₂₃H₂₄ClN₃O₅
分子量:
457.91
性状:
白色结晶固体
熔点:
213-218°C
沸点:
782.9°C at 760mmHg
闪点:
427.3°C
溶解性:
DMSO:45.8 mg/mL (100 mM)
保存条件:
Dry,RT
InChIKey:
DGHHQBMTXTWTJV-BQAIUKQQSA-N
InChI:
InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
Pubchem ID:
危化品级别:
危害声明:
H302-H315-H319-H332-H335
警示性声明:
P280-P305+P351+P338-P310
危险类别码:
R25
关于的化合物详细属性等信息,点击“盐酸拓扑替康”
盐酸拓扑替康用途是什么?
提问时间:2021/6/30 12:59:38
盐酸拓扑替康是做什么用的?哪里可以用到盐酸拓扑替康?
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回复内容:
1
admin2021-08-30 09:42:16
盐酸拓扑替康用作抗肿瘤药;一种拓扑异构酶I抑制剂。Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.;一种具有抗癌活性的 拓扑异构酶I抑制剂。
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