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- 4-氨基-[2,3'-二噻吩]-5-甲酰胺,98%
4-氨基-[2,3'-二噻吩]-5-甲酰胺,98%
SC-514
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中文名称:
4-氨基-[2,3'-二噻吩]-5-甲酰胺
英文名称:
SC-514
CAS No.:
354812-17-2
分子式:
C₉H₈N₂OS₂
分子量:
224.30
熔点:
209-211°C
沸点:
399.2°C at 760 mmHg
闪点:
195.2°C
溶解性:
DMSO:22.4 mg/mL (100 mM);Ethanol:2.2 mg/mL (10 mM)
保存条件:
2-8°C,Dark
InChIKey:
BMUACLADCKCNKZ-UHFFFAOYSA-N
InChI:
InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
Pubchem ID:
危化品级别:
GHS符号:

危害声明:
H301
警示性声明:
P301 + P310
关于的化合物详细属性等信息,点击“354812-17-2”
SC-514用途是什么?
提问时间:2021/8/19 9:09:12
SC-514是做什么用的?哪里可以用到SC-514?
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回复内容:
1
admin2021-08-19 09:09:12
SC-514A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12
碌M for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 碌M). Shown
to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
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