N-(4-甲基-3-((4-(吡啶-3-基)嘧啶-2-基)氨基)苯基)-4-((4-甲基哌嗪-1-基)甲基)苯甲酰胺甲磺酸盐,99%

Imatinib Mesylate

(订货以英文名为准)

产品编号：I20680 CAS：220127-57-1 分子式：C₃₀H₃₅N₇O₄S MDL：MFCD04307699 品牌：Acmec

N-(4-甲基-3-((4-(吡啶-3-基)嘧啶-2-基)氨基)苯基)-4-((4-甲基哌嗪-1-基)甲基)苯甲酰胺甲磺酸盐

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中文名称：

甲磺酸伊马替尼

英文名称：

Imatinib (Mesylate)

CAS No.：

220127-57-1

分子式：

C₃₀H₃₅N₇O₄S

分子量：

589.71

性状：

白色结晶粉末

密度：

0.858 g/mL at 25 °C(lit.)

熔点：

214-224°C

沸点：

133-134 °C(lit.)

闪点：

64°F

溶解性：

DMSO:59 mg/mL (100 mM)

保存条件：

Dry,RT

InChIKey：

YLMAHDNUQAMNNX-UHFFFAOYSA-N

InChI：

InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

Pubchem ID：

123596

危化品级别：

GHS符号：

危害声明：

H302

关于的化合物详细属性等信息，点击“220127-57-1”

甲磺酸伊马替尼用途是什么？

提问时间：2021/8/19 9:09:35

甲磺酸伊马替尼是做什么用的?哪里可以用到甲磺酸伊马替尼?

回复内容：

admin2021-08-19 09:09:35

甲磺酸伊马替尼抗肿瘤药物;一种酪氨酸激酶抑制剂,可抑制c-Kit、Bcr-Abl和PDGFR(IC50:100nM)。Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome.