Recombinant human RAB3A protein,BR

基因名： RAB3A
别名： /
全名： RAB3A，member RAS oncogene family
英文名称： Recombinant Human RAB3A Protein
中文名称： RAB3A，RAS致癌基因家族成员
规格： 50ug ; 100ug ; 1mg ; 10ug
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： P20336
Gene ID： 5864
交叉反应： Human Mouse Rat (Pig Bovine)
分子量： 25kDa
区间范围： 1-220aa
背景说明： Small GTP-binding protein that plays a central role in regulated exocytosis and secretion.Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane.Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane.Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed.Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells.Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9.Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1.Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

暂无数据

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