Recombinant Human Alkaline Phosphatase/ALPL/ALP/Akp2,BR

别名： Alkaline Phosphatase;Tissue-Nonspecific Isozyme;AP-TNAP;TNSALP;Alkaline Phosphatase Liver/Bone/Kidney Isozyme;ALPL
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 2mM MgSO4, 0.1mM ZnCl2, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Alkaline Phosphatase，Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family.There are at least four distinct but related alkaline phosphatases in humans: intestinal AP (IAP)，placental AP(PLAP)，germ cell AP (GCAP) and their genes are clustered on chromosome 2，tissue-nonspecific isozyme (TNAP) which gene is located on chromosome 1.Alkaline phosphatases (APs) are dimeric enzymes，it catalyze the hydrolysis of phosphomonoesters with release of inorganic phosphate.The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor.This isozyme may play a role in skeletal mineralization.Mutations in ALPL gene have been linked directly to different forms of hypophosphatasia，characterized by poorly mineralized cartilage and bones，and this disorder can vary depending on the specific mutation since this determines age of onset and severity of symptoms.
来源： Human Cells

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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