Recombinant Human BAFF/BLyS/TNFSF13B,BR

别名： Tumor necrosis factor ligand superfamily member 13B;B lymphocyte stimulator;BLyS;B-cell-activating factor;BAFF;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;TALL-1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family.It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages.Also found in the spleen，lymph node，bone marrow，T-cells and dendritic cells.A lower expression seen in placenta，heart，lung，fetal liver，thymus，and pancreas.Isoform 2 is expressed in many myeloid cell lines.Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA.TNFSF13/APRIL binds to the same 2 receptors.Together，they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Isoform 3 acts as a transcription factor for its own parent gene，in association with NF-kappa-B p50 subunit，at least in autoimmune and proliferative B-cell diseases.The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival.It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.Isoform 2 heteromultimerizes with isoform 1，probably limiting the amount of functional isoform 1 on the cell surface.Isoform 3 is unlikely form trimers or bind to BAFF receptors.Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain，a 21 aa transmembrane segment，and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain.Within aa 134-285 of the ECD，human BAFF shares 72% aa sequence identity with mouse BAFF.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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