Recombinant Human SLAMF4/Natural Killer Cell Receptor 2B4/CD244,BR

别名： Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NKR2B4;h2B4;SLAM family member 4;SLAMF4;CD244;2B4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Natural killer cell receptor 2B4 is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.2B4 interacts with CD48，while other SLAM family proteins interact homophilically.Three additional splice variants of human 2B4 have deletions of the short region between the Ig-like domains，the second Ig-like domain，or a portion of the cytoplasmic tail.2B4 is expressed on all NK cells，γδ T cells，monocytes，some CD4+ and CD8+ T cells，and some dendritic cells.CD48 mediates 2B4+ cell interactions with nearly all hematopoietic cell types，including cells of the same type.2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation.The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors.Ligation of 2B4 with antibodies or CD48 constructs can either directly trigger inhibitory signaling or disrupt an inhibitory interaction，leading to cellular activation.The inhibitory effect is associated with the long form of 2B4，while the activation is associated with the short form.2B4 can also induce signaling through CD48.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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