Recombinant human UBXN1 protein,BR

基因名： UBXN1
别名： SAPK substrate protein 1;UBA/UBX 33.3 kDa protein
全名： UBX domain protein 1
英文名称： Recombinant Human UBXN1 Protein
中文名称： UBX结构域蛋白1
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： Q04323
Gene ID： 51035
交叉反应： Human Mouse Rat (Bovine)
分子量： 34kDa
区间范围： 1-284aa
背景说明： Ubiquitin-binding protein that plays a role in the modulation of innate immune response.Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways.Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS.In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome.This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497).Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446).Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074).Interacts with the BRCA1-BARD1 heterodimer and regulates its activity.Specifically binds 'Lys-6'-linked polyubiquitin chains.Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172).Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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