Recombinant human RAB10 protein,BR

基因名： RAB10
别名： GTP binding protein RAB10;Rab10;RAB10 member RAS oncogene family;RAB10_HUMAN;Ras related GTP binding protein;Ras related GTP binding protein RAB10;Ras-related protein Rab-10;
英文名称： Recombinant Human RAB10 Protein
全名： RAB10，member RAS oncogene family
中文名称： RAB10，RAS癌基因家族成员
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： P61026
Gene ID： 10890
交叉反应： Human Mouse Rat (Chicken Gorilla)
分子量： 22kDa
区间范围： 1-200aa
背景说明： The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164).Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164).That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164).Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity).In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity).Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372).In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity).In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372).May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity).May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280).Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148).When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148).
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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