Recombinant human TYR protein,BR

基因名： TYR
别名： Tyr-DNA phosphodiesterase 2;hTDP2;5'-Tyr-DNA phosphodiesterase;EAPII;EAP2;TTRAP;AD-022
英文名称： Recombinant Human TYR Protein
全名： tyrosinase (oculocutaneous albinism IA)
中文名称： 酪氨酸酶(眼皮肤白化病)
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： P14679
Gene ID： 7299
交叉反应： Human Mouse (Chicken Bovine)
分子量： 41kDa
区间范围： 1-345aa
背景说明： DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate.Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue.The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation.Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2.Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals.Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate.Acts as a regulator of ribosome biogenesis following stress.Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1.Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells.Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation.Involved in non-canonical TGF-beta induced signaling routes.May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.(Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
研究领域： 代谢性疾病研究
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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