Recombinant human FHIT protein,BR

基因名： FHIT
别名： AP3Aase
英文名称： Recombinant Human FHIT Protein
全名： fragile histidine triad gene
中文名称： 脆性组氨酸三联体蛋白
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： P49789
Gene ID： 2272
交叉反应： Human Mouse Rat (Bovine A.thaliana)
分子量： 16kDa
区间范围： 1-147aa
背景说明： Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP.Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP.Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways.Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis.Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+transporters, enhancing mitochondrial calcium uptake.Functions as tumor suppressor.
研究领域： 癌症研究与治疗
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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