Recombinant human CHMP2A protein,BR

基因名： CHMP2A
别名： BC 2;BC2;Charged multivesicular body protein 2a;CHM2A_HUMAN;CHMP2;CHMP2a;Chromatin modifying protein 2a;Chromatin-modifying protein 2a;hVps2 1;hVps2-1;putative breast adenocarcinoma marker;Putative breast adenocarcinoma marker BC-2;Putative breast adenocarcinoma marker BC2;Vacuolar protein sorting associated protein 2 1;Vacuolar protein sorting-associated protein 2-1;Vps2 1;VPS2;Vps2-1;VPS2A;
英文名称： Recombinant Human CHMP2A Protein
全名： chromatin modifying protein 2A
中文名称： 染色质修饰蛋白2A
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： O43633
Gene ID： 27243
交叉反应： Human Mouse (Chicken)
分子量： 24kDa
区间范围： 1-222aa
背景说明： Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966).Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712).ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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