Recombin human SNAI2 protein,BR

基因名: SNAI2
别名: SLUG;SLUGH;SLUGH1;SNAIL2;WS2D
全名: Zinc finger protein SNAI2
英文名称: Recombinant human SNAI2 protein
中文名称: 锌指蛋白SNAI2
规格: 50ug ; 100ug ; 1mg ; 10ug
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

Swiss Prot： O43623
Gene ID： 6591
交叉反应： Human Mouse Rat (Bovine)
分子量： 30kDa
区间范围： 1-268aa
背景说明： Transcriptional repressor that modulates both activator-dependent and basal transcription.Involved in the generation and migration of neural crest cells.Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity).Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells.In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes.Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes.Represses E-Cadherin/CDH1 transcription via E-box elements.Involved in osteoblast maturation.Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts.Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts.Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

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