Recombinant human MUL1 protein,BR

基因名： MUL1
别名： MUL1;C1orf166;GIDE;MAPL;MULAN;RNF218;mitochondrial E3 ubiquitin protein ligase 1
全名： mitochondrial E3 ubiquitin ligase 1
英文名称： Recombinant Human MUL1 Protein
中文名称： 线粒体E3泛素连接酶1
规格： 10ug ; 50ug ; 100ug ; 1mg
外观(性状)： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度： ≥85% by SDS-PAGE.
储存条件： Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件： 冷藏运输
浓度： 1mg/ml by SDS-PAGE.

Swiss Prot： Q969V5
Gene ID： 79594
交叉反应： Human Mouse (Zebrafish Fruit fly)
分子量： 23kDa
区间范围： 30-236aa
背景说明： Exhibits weak E3 ubiquitin-protein ligase activity.E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation.Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations.Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization .Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway.May also be involved in the sumoylation of the membrane fission protein DNM1L.Inhibits cell growth.When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis.Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response.Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
研究领域： 代谢性疾病研究
应用： Immunology research
来源： E.coli

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： NO
标签信息： With a 6×His tag at the N/C-terminus.

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