Recombinant Human IL-5 R α/CD125/Interleukin-5 Receptor Subunit α,BR

别名： Interleukin-5 receptor subunit alpha;IL-5 receptor subunit alpha;IL-5R subunit alpha;IL-5R-alpha;IL-5RA;CDw125;CD125;IL5RA;IL5R
英文名称： Recombinant Human IL-5 R alpha/CD125/Interleukin-5 Receptor Subunit Alpha
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： 冷藏运输

背景说明： Interleukin-5 Receptor alpha (IL-5Rα，CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology.Mature human IL-5 Rα consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif，a 20 aa transmembrane segment，and a 58 aa cytoplasmic domain.Within the ECD，human IL-5Rα shares 71% aa sequence identity with mouse and rat IL-5 Rα.Alternate splicing of human IL-5 Rα generates soluble secreted forms which function as IL-5 antagonists.The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Rα and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF.IL-5 Rα binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex.IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Rα followed by eosinophilic differentiation and activation.
来源： Human Cells

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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