Recombinant Mouse Legumain/Asparaginyl Endopeptidase/AEP,BR

别名： Legumain;Lgmn;Asparaginyl endopeptidase;Protease cysteine 1;Prsc1
英文名称： Recombinant Mouse Legumain/Asparaginyl Endopeptidase/AEP
中文名称： 重组小鼠Legumain/Asparaginyl Endopeptidase/AEP
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,20% Glycerol,pH8.0.Note:The enzyme achieves its activity under acidic pH.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件： 干冰运输

背景说明： Mouse Legumain，also known as LGMN，is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly.LGMN has a strict specificity for hydrolysis of asparaginyl bonds.It can also cleave aspartyl bonds slowly，especially under acidic conditions.The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.It plays a role in the regulation of cell proliferation via its role in EGFR degradation.Legumain deficiency causes the accumulation of pro-Cathepsins B，H and L，another group of lysosomal cysteine proteases.Overexpression of Legumain in tumors is significant for invasion/metastasis.Mammalian legumain is inhibited by iodoacetamide and maleimides.Legumain activation appears to be autocatalytic and can be triggered by acidic pH.
来源： Human Cells

内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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