Recombinant Human Semaphorin 5A/SEMA5A,BR

别名： Semaphorin-5A;Semaphorin-F;Sema F;SEMA5A;SEMAF
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Semaphorin-5A (SEMA5A) is a member of the Semaphorin family of axon guidance molecules.SEMA5A is a 140 kDa protein.Class 5 Semaphorins are type I transmembrane glycoproteins with an N- terminal Sema domain and multiple juxtamembrane type 1 Thrombospondin (TSP) repeats within their extracellular domains.SEMA5A is expressed in neuroepithelial cells surrounding retinal axons，oligodendrocytes，the base of limb buds，the mesoderm surrounding cranial vessels，and the cardiac atrial septum and endocardial cushions，Human SEMA5A cDNA encodes a signal sequence，a extracellular domain (ECD)，a transmembrane sequence and an cytoplasmic portion.SEMA5A mutations have been implicated in the genetic syndrome，cri-du-chat，while some polymorphisms may increase risk for neurodegenerative diseases such as Parkinson.The expression of SEMA5A may be upregulated in metastatic cancer cells and downregulated in autism.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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