Recombinant Mouse IL-18/IL-1F4,BR

别名： Interleukin-18;Il18;Interferon gamma-inducing factor;IFN-gamma-inducing factor;Interleukin-1 gamma;IL-1 gamma;Igif
英文名称： Recombinant Mouse IL-18/IL-1F4
中文名称： 重组小鼠IL-18/IL-1F4
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mMTris,1mMEDTA,2mMDTT,5%Trehaiose,pH8.0.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： 冷藏运输

背景说明： Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family.It is expressed as a 24 kDa precursor by endothelial and epithelial cells，keratinocytes，gamma δ T cells，and phagocytes.Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18，respectively.IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex.Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs.It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.In the presence of IL-12 or IL-15，IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells.In the absence of IL-12 or IL-15，however，IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.
来源： E.coli

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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