Recombinant Human Artemin,BR

别名： Artemin;ARTN;Enovin;Neublastin;EVN
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules.It is synthesized as a preproprotein，and contains a variable length pre-，or signal sequence，plus a 68 amino acid (aa) proregion and a 113 aa mature segment.Following synthesis and proteolytic processing，mature ARTN is secreted as a presumably glycosylated，28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif.In the mature region，human ARTN is 89% and 88% aa identical to rat and mouse ARTN，respectively.Human ARTN is active on rodent cells.The receptor for ARTN has been identified as the ligand binding subunit GFRα-3 plus the signal transducing subunit，RET.The GFRα-1/RET receptor complex has also been suggested to be a ligand binding unit for ARTN.ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system.It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system.Finally，it has been reported to reverse neuropathic pain due to nerve injury，and to help resolve morphological changes associated with nerve damage.
来源： E.coli

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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