Recombinant Human CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule,BR

别名： Platelet endothelial cell adhesion molecule;PECAM-1;EndoCAM;GPIIA;PECA1;CD31;PECAM1
中文名称: Recombinant Human CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA，pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Platelet Endothelial Cell Adhesion Molecule (PECAM1，CD31)，is a heavily glycosylated transmembrane protein belonging to theimmunoglobulin (Ig) superfamily of cell adhesion molecules.CD31 is composed of an extracellular domain (ECD) of 574 amino acids (aa) containing six Ig-likedomains，a transmembrane domain，and a 118 aacytoplasmic domain.CD31 is highly expressed on endothelial cells and at a lower level on platelets，granulocytes，macrophages，dendritic cells，T and B cells，and natural killer (NK) cells.It is involved in cell adhesion and is required for transepithelial migration of leukocytes (TEM).CD31 acts as a homophilic receptor through itsextracellular domain and is involved in downstream signaling via its cytoplasmic domain.This domain contains highly conserved ITIM motifs which，once tyrosinephosphorylated，recruit and activate the signaling molecules Src and SHP2.The resulting inhibition of TCR signaling increases the activation threshold ofT cells，thus reinforcing peripheral tolerance and preventing development of autoimmunity.CD31 additionally regulates immune responses by acting as a keyinhibitory receptor in dendritic cell development.CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells.
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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