Anti-SERPINB1 Polyclonal Antibody,BR

英文名称： Anti-SERPINB1 Polyclonal Antibody
中文名称： 丝氨酸蛋白酶抑制剂肽酶抑制剂分枝B(卵清蛋白)成员1抗体
规格： 50ul ; 100ul ; 20ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Human
应用： WB ; IHC-P
稀释比例： WB 1:1000-3000. IHC-P 1:50-200.

靶标： SERPINB1
别名： EI;ELANH2;HEL-S-27;HEL57;LEI;M/NEI;MNEI;PI-2;PI2
背景说明： Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Swiss Prot： P30740
Gene ID： 1992
亚细胞定位： Cytoplasm Secreted
免疫原： Recombinant protein of human SERPINB1Public Immunogen Range 1-350aa
理论分子量： 26/43kDa

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

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