Anti-DDX1 Polyclonal Antibody,BR

英文名称： Anti-DDX1 Polyclonal Antibody
中文名称： DEAD盒多肽1抗体
规格： 50ul ; 100ul ; 20ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Human ; Rat ; Mouse预测
交叉反应： Cow(98.0%);Chicken(94.6%)
应用： WB ; IHC-P
稀释比例： WB 1:1000-3000. IHC-P 1:50-200.

靶标： DDX1
别名： ATP dependent helicase DDX1, ATP-dependent helicase DDX1, ATP-dependent RNA helicase DDX1, DBP RB, DBP-RB, DDX1, DDX1_HUMAN, DEAD (Asp Glu Ala Asp) box polypeptide 1, DEAD box 1, DEAD box polypeptide 1, DEAD box protein 1, DEAD box protein retinoblastoma, DEAD-box protein 1, DEAD-box protein-retinoblastoma, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 1
背景说明： Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA.
Swiss Prot： Q92499
Gene ID： 1653
亚细胞定位： Cytoplasm Nucleus
研究领域： 表观遗传 ; 细胞生物学
免疫原： Recombinant protein of human DDX1Public Immunogen Range 391-740aa
理论分子量： 70/82kDa

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

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