Anti-phospho-LATS2(Ser83) Polyclonal Antibody,BR

英文名称： Anti-phospho-LATS2(Ser83)Polyclonal Antibody
中文名称： phospho-LATS2(Ser83) 多克隆抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Rat预测
交叉反应： Human;Mouse;Dog;Pig;Cow;Horse
应用： IHC-P ; IHC-F ; IF
稀释比例： IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.

靶标： phospho-LATS2(Ser83)
别名： Kinase phosphorylated during mitosis;KPM;Large tumor suppressor homolog 2;Large tumor suppressor homolog 2 Drosophila;LATS large tumor suppressor Drosophila homolog 2
背景说明： Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Swiss Prot： Q9NRM7
Gene ID： 26524
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human LATS2 around the phosphorylation site of Ser83
理论分子量： 120-150kDa

纯化方法： Affinity purification
储存液： 0.01M TBS (pH7.4) with 1% BSA， 0.02% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

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