Anti-Phospho-PRKCG (Thr514) Polyclonal Antibody,BR

英文名称： Anti-Phospho-PRKCG(Thr514)Polyclonal Antibody
中文名称： 蛋白激酶C
亚型：G抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Mouse预测
交叉反应： Human;Rat;Chicken;Pig;Cow;Horse;Rabbit
应用： IHC-P ; IHC-F ; IF
稀释比例： IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.

靶标： Phospho-PRKCG (Thr514)
别名： PKC gamma (phospho T514);p-PKC gamma (phospho T514);PKC gamma (Phospho Thr514);PKC gamma (Phospho T514);p-PKC gamma (Thr514);p-PKC gamma (Thr514);PKCC;PKCG;PRKCG
背景说明： Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage.
Swiss Prot： P05129
Gene ID： 5582
亚细胞定位： Cytoplasm Cell membrane
研究领域： 肿瘤&癌症 ; 免疫学 ; 信号传导
免疫原： A synthetic peptide of human PKC gamma around the phosphorylation site of Thr514
理论分子量： 78kDa

纯化方法： Affinity purification
储存液： 0.01M TBS (pH7.4) with 1% BSA， 0.02% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.
运输条件： 冷冻运输

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