Anti-ABCB1 Polyclonal Antibody,BR

英文名称： Anti-ABCB1 Polyclonal Antibody
中文名称： 多药耐药蛋白/P-糖蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Rat ; Mouse
应用： WB ; IF/ICC ; ELISA
稀释比例： WB 1:500-1000. IF/ICC 1:50-200.

靶标： ABCB1
别名： ABC20, ABCB1, ATP binding cassette, sub family B (MDR/TAP), member 1, ATP-binding cassette sub-family B member 1, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, GP170, MDR1, MDR1_HUMAN, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, P-glycoprotein 1, PGY1
背景说明： The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Swiss Prot： P08183
Gene ID： 5243
亚细胞定位： Cell membrane Multi-pass membrane protein
研究领域： 肿瘤&癌症 ; 新陈代谢 ; 干细胞
免疫原： Recombinant protein of human ABCB1Public Immunogen Range 603-692aa
理论分子量： 141kDa

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。