Anti-PTEN Polyclonal Antibody,BR

英文名称： Anti-PTEN Polyclonal Antibody
中文名称： 同源性磷酸酶-张力蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Rat ; Mouse ; Human
应用： WB ; IHC-P ; IF/ICC ; ELISA
稀释比例： WB 1:500-1000. IHC-P 1:50-200. IF/ICC 1:50-200.

靶标： PTEN
别名： 10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1
背景说明： This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Swiss Prot： P60484
Gene ID： 5728
亚细胞定位： Cytoplasm Nucleus PML body Secreted
研究领域： 新陈代谢 ; 发育生物学 ; 信号传导 ; 表观遗传
免疫原： Recombinant protein of human PTENPublic Immunogen Range 1-200aa
理论分子量： 47kDa

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。