Anti-CD274 Polyclonal Antibody,BR

英文名称： Anti-CD274 Polyclonal Antibody
中文名称： CD274 多克隆抗体
规格： 100ul ; 50ul
宿主： Rabbit
亚型： IgG
交叉反应： Rat ; Human ; Mouse
应用： WB ; IHC-P ; IF-P ; ELISA
稀释比例： WB 1:500-2000. IHC-P 1:50-200. IF-P 1:50-200.

靶标： CD274
别名： B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1
背景说明： This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Swiss Prot： Q9NZQ7
Gene ID： 29126
亚细胞定位： Cell membrane Endomembrane system Single-pass type I membrane protein
研究领域： 免疫学 ; 神经学
免疫原： A synthetic peptide of human CD274Public Immunogen Range 190-290aa
理论分子量： 20/33kDa

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。