兔心钠肽检测yabo官网手机版 盒,BR

中文名称： 兔心钠肽检测yabo官网手机版 盒
英文名称： Rabbit ANP ELISA Kit
别名： ANF; ANP; ANPatriopeptin; ATFB6; atrial natriuretic factor; Atrial Natriuretic Peptide; Cardionatrin; CDD-ANF; natriuretic peptide A; natriuretic peptide precursor A; NPPA; PND; PNDcardionatrin; prepronatriodilatin
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： ANP
样品类型： 血清/血浆/细胞培养上清
反应性： Rabbit
应用： ELISA
定量/定性： 定量检测
检测范围： 31.2-2，000pg/mL
灵敏度： 15pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h30min

Swiss Prot： P07500
Gene ID： 100009087
背景说明： Atrial natriuretic peptide (ANP) is a powerful vasodilator, and a protein hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and adipose tissue. It is released by atrial myocytes in response to high blood volume. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP has exactly the opposite function of the aldosterone secreted by the zona glomerulosa in regard to its effect on sodium in the kidney that is, aldosterone stimulates sodium retention and ANP generates sodium loss. Incardiac myocytes, ANP is made as a precursor form, i.e. prepro-ANP, a polypeptide of 151 amino acids. After the signal peptide is removed in the endoplasmic reticulum, the 126-amino-acid pro-ANP is stored in the intracellular granules. When the cells are stimulated, pro-ANP is released and converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin.ANP interacts with three receptors including guanylyl cyclase-A (NPR1), guanylyl cyclase-B (NPR2), natriuretic peptide clearance receptor (NPR3). The binding of ANP to its receptor causes the conversion of GTP to cGMP and raises intracellular cGMP. Receptor-agonist binding causes a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system. ANP and related peptides are used as biomarkers for cardiovascular diseases such as stroke, coronary artery disease, myocardial infarction and heart failure.

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