ACE-2(Mammalian，C-mFc),BR

规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4 .
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

背景说明： Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family，the ACE family includes somatic and germinal ACE.ACE-2 cleaves angiotensins I and II as a carboxypeptidase，ACE-2 converts angiotensin I to angiotensin 1-9，and angiotensin II to angiotensin 1-7.ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency.ACE-2 can be high expressed in testis，kidney and heart，in colon，small intestine and ovary at moderate levels.Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity.ACE-2 may play an important role in regulating the heart function.

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