Recombinant Human Interleukin-4 Receptor Subunit Alpha/IL-4 Rα(Fc fusion),BR

别名： Interleukin-4 receptor subunit alpha;IL-4 receptor subunit alpha;IL-4R subunit alpha;IL-4R-alpha;IL-4RA;CD124;IL-4-binding protein;IL4-BP;IL4R;IL4RA
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

背景说明： Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family.Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain，a 24 aa transmembrane segment，and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif.IL4-Ra plays an important role in Th2-biased immune responses，alternative macrophage activation，mucosal immunity，allergic inflammation，tumor progression，and atherogenesis.Soluble forms of IL4-Ra，generated by alternate splicing or proteolysis，retain ligand binding properties and inhibit IL-4 bioactivity.IL4-Ra is a component of two distinct receptor complexes and shows species selectivity between human and mouse.It can associate with the common gamma chain (γc) to form the IL-4 responsive type I receptor in which γc increases the affinity for IL-4 and enables signaling.It can alternatively associate with IL13-Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13.The use of shared receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other cytokines that utilize γc.
来源： Human cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human Interleukin-4 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Met26-Gln231 is expressed with a Fc tag at the C-terminus.

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