Recombinant Human CD340/ERBB2/HER2,BR

别名： Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;Proto-oncogene Neu;Tyrosine kinase-type cell surface receptor HER2;ERBB2;MLN19;NGL;TKR1
英文名称： Recombinant Human CD340/ERBB2/HER2
中文名称： 重组人CD340/ERBB2/HER2
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： 冷藏运输

背景说明： Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein，and belongs to the epidermal growth factor (EGF) receptor family.HER2 plays a key role in development，cell proliferation and differentiation.HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas，including breast，prostate，ovarian，lung cancers and so on.HER2 is activated by dimerization and not activated by EGF，TGF-alpha and amphiregulin.Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR，ERBB3 and ERBB4.HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription.It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC.And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
来源： Human cells

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles
内毒素： Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc tag at the C-terminus.

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