Recombinant Human IL-10,BR

别名： Interleukin-10;IL-10;Cytokine synthesis inhibitory factor;CSIF;IL10;RP11-262N9.1;IL10A;MGC126450;MGC126451;TGIF
英文名称： Recombinant Human IL-10
中文名称： 重组人IL-10
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： 冷藏运输

背景说明： Interleukin 10(IL10)，also known as cytokine synthesis inhibitory factor (CSIF)，is a secreted protein and belongs to the IL-10 family.IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells，keratinocytes，and placental cytotrophoblasts.IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage.As IL-10 in produced in several T helper populations，it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells.Once expressed，IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3.As IL-10 is a strong inhibitor of inflammation，it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions.In addition to elevated levels in parasitic infection，high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency.The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations
来源： Human cells

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human Interleukin-10 is produced by our Mammalian expression system and the target gene encoding Ser19-Asn178 is expressed.

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